Title: Circadian network dynamics in Drosophila


Host Institution: University of Leicester
SupervisorDr Ezio Rosato
Secondment: Jagiellonian University (Krakow) for 4 months for synaptic plasticity studies of the fly brain.


Objectives: To determine which of two alternative models, the network model or the M/E oscillator best describes the way in which the fly clock functions. We will use further novel tools that we will generate to explore how the clock functions at the neuronal level by comparing neuronal activation dynamics with the traditional read-out of clock protein dynamics.


About me: I come from Marseille, in the south of the France. During my studies, I specialised in biology as soon as I could. I am curious about many sides of biology and it took me time to decide in which field I really wanted to work. This is why I did a multidisciplinary master on Development, Immunology and Neurology. During my internships, I had the opportunity to work on memory and spatial navigation at the INMED (Mediterranean Neurology Institute). My goal was to assess if there was a correlation between the presence of objects in the maze and the pupil dilation of the mouse. I also worked on another field of biology in the CIML (Immunology Center of Marseille Luminy) and tested if a high level of cholesterol in the mother during pregnancy could influence the lymph node development of the embryo. These projects introduced me to research in neurology and allowed me to realise my desire to participate in the evolution of knowledge in the field.

My project on CINCHRON will be to dissect the fly clock and to understand how the neural network induce a circadian rhythm by using state of the art genetic technologies.

By joining CINCHRON program, I integrate a massive team working on the same subject but on different sides of it : the chronobiology. Exchanging point of views with other students and expert researchers working on other projects is a must if we want to understand biology as a whole. I hope that my researches will help to improve our knowledge on chronobiology from the program but also for the scientific community.